Cytogenotoxicity and protective effect of piperine and capsaicin on meristematic cells of Allium cepa L.

Piperine and capsaicin are important molecules with biological pharmacological activities. This study aimed to evaluate the cytogenotoxic protective effect of piperine on Allium cepa cells. A. roots were exposed negative (2% Dimethylsulfoxide) positive (Methylmethanesulfonate, MMS, 10 µg/mL) controls, four concentrations (25-200 µM) or (alone) associated before, simultaneously after MMS. Only lowest concentration (25 showed a because it was not genotoxic. cytotoxic (50, 100 200 µM). (50 caused significant increase in total average chromosomal alterations For capsaicin, genotoxic dose-dependent for all concentrations, highlighting presence micronuclei nuclear buds two isolates. In general, bioactive compounds reduced against damage by mainly and/or buds. Therefore, at highest did have cytoprotective action, demonstrated chemopreventive activity.